Target name

P62943: Peptidyl-prolyl cis-trans isomerase FKBP1A


  Protein function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

  Database links

Uniprot primary ID P62943
PDB ID 3J8H
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID ocu:100328942
DIP ID DIP-61479N
STRING ID 9986.ENSOCUP00000008526
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100328942
BindingDB P62943

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.969 0.003 0.953 0.000 0.961 0.003 0.961 0.003 0.990 0.000 0.926 0.005 Download
Estate fingerprints 0.961 0.006 0.879 0.000 0.920 0.000 0.921 0.003 0.970 0.000 0.841 0.006 Download
MACCS fingerprints 0.941 0.003 0.949 0.004 0.945 0.005 0.945 0.005 0.990 0.000 0.891 0.007 Download
Daylight fingerprints 0.900 0.000 0.980 0.005 0.940 0.000 0.940 0.000 0.970 0.000 0.888 0.004 Download
ECFP2 fingerprints 0.988 0.004 0.992 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP6 fingerprints 0.971 0.003 1.000 0.000 0.986 0.005 0.986 0.005 1.000 0.000 0.971 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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