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E-mail: biomed@csu.edu.cn
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Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
| Uniprot primary ID | P62943 |
| PDB ID | 3J8H |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | ocu:100328942 |
| DIP ID | DIP-61479N |
| STRING ID | 9986.ENSOCUP00000008526 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 100328942 |
| BindingDB | P62943 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.969 | 0.003 | 0.953 | 0.000 | 0.961 | 0.003 | 0.961 | 0.003 | 0.990 | 0.000 | 0.926 | 0.005 | Download |
| Estate fingerprints | 0.961 | 0.006 | 0.879 | 0.000 | 0.920 | 0.000 | 0.921 | 0.003 | 0.970 | 0.000 | 0.841 | 0.006 | Download |
| MACCS fingerprints | 0.941 | 0.003 | 0.949 | 0.004 | 0.945 | 0.005 | 0.945 | 0.005 | 0.990 | 0.000 | 0.891 | 0.007 | Download |
| Daylight fingerprints | 0.900 | 0.000 | 0.980 | 0.005 | 0.940 | 0.000 | 0.940 | 0.000 | 0.970 | 0.000 | 0.888 | 0.004 | Download |
| ECFP2 fingerprints | 0.988 | 0.004 | 0.992 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.005 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP6 fingerprints | 0.971 | 0.003 | 1.000 | 0.000 | 0.986 | 0.005 | 0.986 | 0.005 | 1.000 | 0.000 | 0.971 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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