Target name

P62993: Growth factor receptor-bound protein 2


  Protein function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

  Database links

Uniprot primary ID P62993
PDB ID 2H5K 1AZE 1GRI 3OV1 1BM2 1GHU 3KFJ 4P9V 1JYR 1JYQ 1FYR 1JYU 1GFC 2W0Z 1TZE 1GFD 3WA4 1FHS 1QG1 4P9Z 2H46 3S8O 3S8L 3N8M 1ZFP 3IN8 2VWF 3IN7 3N7Y 2VVK 3S8N 1X0N 2AOB 1CJ1 2AOA 3C7I 1GCQ 3N84 3MXC 1IO6 3MXY 3IMD 3IMJ 1BMB 3OVE 2HUW
DrugBank ID DB00061
BioGrid ID 109142
GuidetoPHARMACOLOGY ID
PharmGKB ID PA28962
KEGG ID hsa:2885
DIP ID DIP-29229N
STRING ID 9606.ENSP00000339007
IntAct ID P62993
DMDM 51702266
BRENDA
Reactome R-HSA-5654720 R-HSA-912631 R-HSA-5663213 R-HSA-5655332 R-HSA-1295596 R-HSA-354194 R-HSA-114604 R-HSA-5654688 R-HSA-1963640 R-HSA-2219530 R-HSA-1963642 R-HSA-5654732 R-HSA-5654710 R-HSA-186763 R-HSA-180292 R-HSA-1257604 R-HSA-5654 R-HSA-2730905 R-HSA-74751
SignaLink P62993
BioCyc
Entrez Gene (Gene ID) 2885
BindingDB P62993

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.980 0.000 0.960 0.005 0.970 0.000 0.970 0.000 0.980 0.000 0.940 0.000 Download
Estate fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.959 0.003 Download
MACCS fingerprints 0.980 0.000 0.960 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.943 0.005 Download
Daylight fingerprints 0.969 0.003 0.977 0.000 0.973 0.005 0.973 0.005 0.980 0.000 0.949 0.003 Download
ECFP2 fingerprints 0.980 0.000 0.972 0.004 0.976 0.005 0.976 0.005 0.990 0.000 0.952 0.004 Download
ECFP4 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.956 0.007 Download
ECFP6 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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