Target name

P68400: Casein kinase II subunit alpha


  Protein function

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).

  Database links

Uniprot primary ID P68400
PDB ID 4BXB 3NGA 3RPS 4IB5 3BQC 3C13 3FWQ 4UBA 4GRB 3AMY 4BXA 4MD7 4MD9 4MD8 5CQW 5CQU 3WIL 1PJK 3WIK 3OWJ 3AT3 3TAX 3OWK 1NA7 3OWL 4FBX 4RLL 3WOW 4GYY 3JUH 3MB7 4GUB 4GYW 3AT2 3U9C 3AXW 4GZ3 3WAR 1JWH 2ZJW 2PVR 4NH1 3NSZ 3U4U 4KWP 3R0T 3AT4 4DGL 3U87 3Q04 4UB7
DrugBank ID
BioGrid ID 107841
GuidetoPHARMACOLOGY ID 1549
PharmGKB ID PA26957
KEGG ID hsa:1457
DIP ID DIP-32682N
STRING ID 9606.ENSP00000217244
IntAct ID P68400
DMDM 55977123
BRENDA 2.7.11.1
Reactome R-HSA-445144 R-HSA-201688 R-HSA-2514853
SignaLink P68400
BioCyc
Entrez Gene (Gene ID) 1457
BindingDB P68400

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.946 0.006 0.893 0.005 0.885 0.005 0.940 0.000 0.788 0.009 Download
Estate fingerprints 0.731 0.007 0.833 0.004 0.782 0.004 0.772 0.004 0.889 0.003 0.570 0.007 Download
MACCS fingerprints 0.840 0.000 0.816 0.008 0.828 0.004 0.832 0.006 0.891 0.003 0.660 0.011 Download
Daylight fingerprints 0.734 0.015 0.968 0.009 0.851 0.009 0.831 0.011 0.923 0.005 0.726 0.016 Download
ECFP2 fingerprints 0.842 0.006 0.908 0.008 0.875 0.005 0.871 0.007 0.930 0.000 0.750 0.012 Download
ECFP4 fingerprints 0.825 0.005 0.935 0.007 0.880 0.005 0.871 0.006 0.935 0.005 0.762 0.009 Download
ECFP6 fingerprints 0.815 0.005 0.963 0.003 0.889 0.003 0.879 0.003 0.930 0.000 0.783 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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