Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
| Uniprot primary ID | P78536 |
| PDB ID | 3CKI 3EWJ 1ZXC 3E8R 3LE9 2M2F 2OI0 2FV5 2I47 3B92 2FV9 2DDF 3G42 3LEA 3O64 3EDZ 1BKC 3KME 3KMC 2A8H 3LGP 3L0T 3L0V |
| DrugBank ID | |
| BioGrid ID | 112731 |
| GuidetoPHARMACOLOGY ID | 1662 |
| PharmGKB ID | PA24512 |
| KEGG ID | hsa:6868 |
| DIP ID | DIP-31044N |
| STRING ID | 9606.ENSP00000309968 |
| IntAct ID | P78536 |
| DMDM | 14423632 |
| BRENDA | 3.4.24.86 |
| Reactome | R-HSA-2691232 R-HSA-193692 R-HSA-982772 R-HSA-1442490 R-HSA-2644606 R-HSA-2660826 R-HSA-75893 R-HSA-2122948 R-HSA-2894862 R-HSA-177929 R-HSA-1251985 R-HSA-5362798 |
| SignaLink | P78536 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6868 |
| BindingDB | P78536 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.846 | 0.005 | 0.934 | 0.000 | 0.890 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.789 | 0.003 | Download |
| Estate fingerprints | 0.874 | 0.005 | 0.848 | 0.000 | 0.861 | 0.003 | 0.867 | 0.005 | 0.940 | 0.000 | 0.729 | 0.003 | Download |
| MACCS fingerprints | 0.790 | 0.000 | 0.890 | 0.000 | 0.840 | 0.000 | 0.836 | 0.005 | 0.950 | 0.000 | 0.690 | 0.000 | Download |
| Daylight fingerprints | 0.844 | 0.005 | 0.876 | 0.005 | 0.860 | 0.000 | 0.860 | 0.000 | 0.909 | 0.003 | 0.721 | 0.003 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.933 | 0.005 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.960 | 0.000 | 0.980 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.944 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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