Target name

P78536: Disintegrin and metalloproteinase domain-containing protein 17


  Protein function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

  Database links

Uniprot primary ID P78536
PDB ID 3CKI 3EWJ 1ZXC 3E8R 3LE9 2M2F 2OI0 2FV5 2I47 3B92 2FV9 2DDF 3G42 3LEA 3O64 3EDZ 1BKC 3KME 3KMC 2A8H 3LGP 3L0T 3L0V
DrugBank ID
BioGrid ID 112731
GuidetoPHARMACOLOGY ID 1662
PharmGKB ID PA24512
KEGG ID hsa:6868
DIP ID DIP-31044N
STRING ID 9606.ENSP00000309968
IntAct ID P78536
DMDM 14423632
BRENDA 3.4.24.86
Reactome R-HSA-2691232 R-HSA-193692 R-HSA-982772 R-HSA-1442490 R-HSA-2644606 R-HSA-2660826 R-HSA-75893 R-HSA-2122948 R-HSA-2894862 R-HSA-177929 R-HSA-1251985 R-HSA-5362798
SignaLink P78536
BioCyc
Entrez Gene (Gene ID) 6868
BindingDB P78536

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.846 0.005 0.934 0.000 0.890 0.000 0.890 0.000 0.960 0.000 0.789 0.003 Download
Estate fingerprints 0.874 0.005 0.848 0.000 0.861 0.003 0.867 0.005 0.940 0.000 0.729 0.003 Download
MACCS fingerprints 0.790 0.000 0.890 0.000 0.840 0.000 0.836 0.005 0.950 0.000 0.690 0.000 Download
Daylight fingerprints 0.844 0.005 0.876 0.005 0.860 0.000 0.860 0.000 0.909 0.003 0.721 0.003 Download
ECFP2 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.933 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.944 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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