Target name

P79208: Prostaglandin G/H synthase 2


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

  Database links

Uniprot primary ID P79208
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID oas:443460
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA 1.14.99.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 443460
BindingDB P79208

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.904 0.010 0.904 0.004 0.904 0.005 0.905 0.005 0.978 0.004 0.811 0.006 Download
Estate fingerprints 0.910 0.009 0.888 0.005 0.899 0.006 0.899 0.006 0.940 0.000 0.801 0.012 Download
MACCS fingerprints 0.880 0.000 0.896 0.000 0.888 0.004 0.888 0.004 0.960 0.000 0.777 0.007 Download
Daylight fingerprints 0.736 0.007 0.796 0.005 0.766 0.005 0.760 0.005 0.838 0.004 0.537 0.007 Download
ECFP2 fingerprints 0.979 0.006 0.895 0.004 0.937 0.005 0.941 0.006 0.990 0.000 0.880 0.008 Download
ECFP4 fingerprints 0.977 0.005 0.911 0.004 0.944 0.005 0.947 0.005 0.990 0.000 0.893 0.007 Download
ECFP6 fingerprints 0.966 0.005 0.950 0.005 0.958 0.004 0.958 0.004 0.990 0.000 0.914 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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