Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
| Uniprot primary ID | P80365 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 109524 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29477 |
| KEGG ID | hsa:3291 |
| DIP ID | |
| STRING ID | 9606.ENSP00000316786 |
| IntAct ID | |
| DMDM | 30316367 |
| BRENDA | 1.1.1.B40 |
| Reactome | R-HSA-194002 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3291 |
| BindingDB | P80365 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.809 | 0.006 | 0.993 | 0.000 | 0.901 | 0.003 | 0.889 | 0.006 | 0.968 | 0.004 | 0.818 | 0.004 | Download |
| Estate fingerprints | 0.835 | 0.007 | 0.939 | 0.003 | 0.887 | 0.005 | 0.881 | 0.003 | 0.950 | 0.000 | 0.779 | 0.007 | Download |
| MACCS fingerprints | 0.757 | 0.008 | 0.937 | 0.005 | 0.847 | 0.007 | 0.829 | 0.007 | 0.927 | 0.005 | 0.701 | 0.010 | Download |
| Daylight fingerprints | 0.690 | 0.000 | 1.000 | 0.000 | 0.850 | 0.000 | 0.820 | 0.000 | 0.971 | 0.003 | 0.730 | 0.000 | Download |
| ECFP2 fingerprints | 0.946 | 0.007 | 0.986 | 0.000 | 0.966 | 0.005 | 0.966 | 0.005 | 0.990 | 0.000 | 0.929 | 0.006 | Download |
| ECFP4 fingerprints | 0.924 | 0.007 | 0.994 | 0.000 | 0.959 | 0.003 | 0.957 | 0.005 | 0.990 | 0.000 | 0.917 | 0.005 | Download |
| ECFP6 fingerprints | 0.896 | 0.010 | 0.998 | 0.000 | 0.947 | 0.005 | 0.941 | 0.006 | 0.990 | 0.000 | 0.890 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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