Target name

P80365: Corticosteroid 11-beta-dehydrogenase isozyme 2


  Protein function

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

  Database links

Uniprot primary ID P80365
PDB ID
DrugBank ID
BioGrid ID 109524
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29477
KEGG ID hsa:3291
DIP ID
STRING ID 9606.ENSP00000316786
IntAct ID
DMDM 30316367
BRENDA 1.1.1.B40
Reactome R-HSA-194002
SignaLink
BioCyc
Entrez Gene (Gene ID) 3291
BindingDB P80365

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.809 0.006 0.993 0.000 0.901 0.003 0.889 0.006 0.968 0.004 0.818 0.004 Download
Estate fingerprints 0.835 0.007 0.939 0.003 0.887 0.005 0.881 0.003 0.950 0.000 0.779 0.007 Download
MACCS fingerprints 0.757 0.008 0.937 0.005 0.847 0.007 0.829 0.007 0.927 0.005 0.701 0.010 Download
Daylight fingerprints 0.690 0.000 1.000 0.000 0.850 0.000 0.820 0.000 0.971 0.003 0.730 0.000 Download
ECFP2 fingerprints 0.946 0.007 0.986 0.000 0.966 0.005 0.966 0.005 0.990 0.000 0.929 0.006 Download
ECFP4 fingerprints 0.924 0.007 0.994 0.000 0.959 0.003 0.957 0.005 0.990 0.000 0.917 0.005 Download
ECFP6 fingerprints 0.896 0.010 0.998 0.000 0.947 0.005 0.941 0.006 0.990 0.000 0.890 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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