Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
| Uniprot primary ID | P80457 |
| PDB ID | 3AX7 3EUB 3AX9 3AMZ 3NRZ 1FO4 1VDV 3B9J 3NS1 1N5X 1V97 3ETR 3NVY 3NVZ 3NVW 3NVV 3BDJ 3AM9 3UNI 1FIQ 3SR6 3UNC 3UNA |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | bta:280960 |
| DIP ID | |
| STRING ID | 9913.ENSBTAP00000016620 |
| IntAct ID | |
| DMDM | |
| BRENDA | 1.17.3.2 1.17.1.4 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 280960 |
| BindingDB | P80457 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.910 | 0.000 | 0.950 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.970 | 0.000 | 0.861 | 0.003 | Download |
| Estate fingerprints | 0.846 | 0.005 | 0.880 | 0.003 | 0.863 | 0.007 | 0.853 | 0.007 | 0.915 | 0.005 | 0.718 | 0.011 | Download |
| MACCS fingerprints | 0.917 | 0.008 | 0.827 | 0.004 | 0.872 | 0.006 | 0.874 | 0.007 | 0.954 | 0.005 | 0.744 | 0.014 | Download |
| Daylight fingerprints | 0.879 | 0.003 | 0.843 | 0.004 | 0.861 | 0.006 | 0.858 | 0.004 | 0.900 | 0.000 | 0.719 | 0.009 | Download |
| ECFP2 fingerprints | 0.902 | 0.004 | 0.930 | 0.005 | 0.916 | 0.005 | 0.911 | 0.003 | 0.980 | 0.000 | 0.827 | 0.007 | Download |
| ECFP4 fingerprints | 0.969 | 0.006 | 0.973 | 0.004 | 0.971 | 0.006 | 0.971 | 0.006 | 0.999 | 0.003 | 0.936 | 0.008 | Download |
| ECFP6 fingerprints | 0.959 | 0.006 | 0.983 | 0.004 | 0.971 | 0.003 | 0.971 | 0.003 | 1.000 | 0.000 | 0.941 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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