TargetNet
  Target name

P80457: Xanthine dehydrogenase/oxidase

  Protein function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.

  Database links
Uniprot primary ID P80457
PDB ID 3AX7 3EUB 3AX9 3AMZ 3NRZ 1FO4 1VDV 3B9J 3NS1 1N5X 1V97 3ETR 3NVY 3NVZ 3NVW 3NVV 3BDJ 3AM9 3UNI 1FIQ 3SR6 3UNC 3UNA
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:280960
DIP ID
STRING ID 9913.ENSBTAP00000016620
IntAct ID
DMDM
BRENDA 1.17.3.2 1.17.1.4
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 280960
BindingDB P80457
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.950 0.000 0.930 0.000 0.930 0.000 0.970 0.000 0.861 0.003 Download
Estate fingerprints 0.846 0.005 0.880 0.003 0.863 0.007 0.853 0.007 0.915 0.005 0.718 0.011 Download
MACCS fingerprints 0.917 0.008 0.827 0.004 0.872 0.006 0.874 0.007 0.954 0.005 0.744 0.014 Download
Daylight fingerprints 0.879 0.003 0.843 0.004 0.861 0.006 0.858 0.004 0.900 0.000 0.719 0.009 Download
ECFP2 fingerprints 0.902 0.004 0.930 0.005 0.916 0.005 0.911 0.003 0.980 0.000 0.827 0.007 Download
ECFP4 fingerprints 0.969 0.006 0.973 0.004 0.971 0.006 0.971 0.006 0.999 0.003 0.936 0.008 Download
ECFP6 fingerprints 0.959 0.006 0.983 0.004 0.971 0.003 0.971 0.003 1.000 0.000 0.941 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn