Target name

P81908: Cholinesterase


  Protein function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity).

  Database links

Uniprot primary ID P81908
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 9796.ENSECAP00000000166
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P81908

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.735 0.007 0.963 0.003 0.849 0.003 0.829 0.006 0.940 0.000 0.713 0.008 Download
Estate fingerprints 0.858 0.004 0.794 0.005 0.826 0.005 0.822 0.004 0.899 0.003 0.654 0.007 Download
MACCS fingerprints 0.932 0.004 0.778 0.005 0.855 0.005 0.860 0.000 0.940 0.000 0.722 0.004 Download
Daylight fingerprints 0.604 0.005 0.986 0.005 0.795 0.005 0.738 0.004 0.812 0.004 0.621 0.003 Download
ECFP2 fingerprints 0.880 0.000 0.948 0.003 0.914 0.005 0.910 0.000 0.980 0.000 0.832 0.004 Download
ECFP4 fingerprints 0.885 0.005 0.981 0.004 0.933 0.005 0.929 0.003 0.980 0.000 0.872 0.004 Download
ECFP6 fingerprints 0.832 0.006 0.998 0.000 0.915 0.005 0.904 0.005 0.980 0.000 0.841 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn