Target name

P97612: Fatty-acid amide hydrolase 1


  Protein function

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).

  Database links

Uniprot primary ID P97612
PDB ID 3K7F 4DO3 3QJ9 3OJ8 3QK5 2VYA 3PPM 3QJ8 3QKV 3LJ7 2WJ2 4HBP 3LJ6 4J5P 2WAP 2WJ1 1MT5 3K84 3PR0 3K83
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:100911581 rno:29347
DIP ID DIP-46284N
STRING ID 10116.ENSRNOP00000015961
IntAct ID
DMDM
BRENDA 3.5.1.99 3.5.1.4
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 29347;100911581
BindingDB P97612

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.728 0.004 0.950 0.000 0.839 0.003 0.819 0.003 0.940 0.000 0.694 0.007 Download
Estate fingerprints 0.756 0.005 0.860 0.005 0.808 0.004 0.798 0.004 0.890 0.000 0.615 0.007 Download
MACCS fingerprints 0.771 0.003 0.903 0.000 0.837 0.005 0.822 0.004 0.930 0.000 0.679 0.003 Download
Daylight fingerprints 0.771 0.003 0.825 0.000 0.798 0.004 0.790 0.000 0.840 0.000 0.594 0.005 Download
ECFP2 fingerprints 0.930 0.005 0.948 0.000 0.939 0.003 0.939 0.003 0.980 0.000 0.873 0.007 Download
ECFP4 fingerprints 0.930 0.000 0.970 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.902 0.004 Download
ECFP6 fingerprints 0.900 0.000 0.988 0.003 0.944 0.005 0.940 0.000 0.990 0.000 0.890 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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