NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
| Uniprot primary ID | Q00960 |
| PDB ID | 3JPW 4PE5 3JPY 3QEM 3QEL |
| DrugBank ID | |
| BioGrid ID | 246575 |
| GuidetoPHARMACOLOGY ID | 457 |
| PharmGKB ID | |
| KEGG ID | rno:24410 |
| DIP ID | DIP-33702N |
| STRING ID | 10116.ENSRNOP00000011697 |
| IntAct ID | Q00960 |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24410 |
| BindingDB | Q00960 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.870 | 0.000 | 0.850 | 0.005 | 0.860 | 0.000 | 0.860 | 0.000 | 0.926 | 0.005 | 0.715 | 0.005 | Download |
| Estate fingerprints | 0.794 | 0.007 | 0.802 | 0.006 | 0.798 | 0.004 | 0.797 | 0.005 | 0.880 | 0.000 | 0.599 | 0.011 | Download |
| MACCS fingerprints | 0.827 | 0.005 | 0.797 | 0.007 | 0.812 | 0.004 | 0.816 | 0.005 | 0.890 | 0.000 | 0.624 | 0.007 | Download |
| Daylight fingerprints | 0.805 | 0.005 | 0.825 | 0.000 | 0.815 | 0.005 | 0.815 | 0.005 | 0.860 | 0.000 | 0.634 | 0.007 | Download |
| ECFP2 fingerprints | 0.891 | 0.006 | 0.929 | 0.005 | 0.910 | 0.000 | 0.909 | 0.003 | 0.960 | 0.000 | 0.820 | 0.005 | Download |
| ECFP4 fingerprints | 0.920 | 0.000 | 0.958 | 0.003 | 0.939 | 0.003 | 0.939 | 0.003 | 0.980 | 0.000 | 0.874 | 0.007 | Download |
| ECFP6 fingerprints | 0.906 | 0.005 | 0.986 | 0.000 | 0.946 | 0.005 | 0.944 | 0.005 | 0.970 | 0.000 | 0.895 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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