Target name

Q00960: Glutamate receptor ionotropic, NMDA 2B


  Protein function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

  Database links

Uniprot primary ID Q00960
PDB ID 3JPW 4PE5 3JPY 3QEM 3QEL
DrugBank ID
BioGrid ID 246575
GuidetoPHARMACOLOGY ID 457
PharmGKB ID
KEGG ID rno:24410
DIP ID DIP-33702N
STRING ID 10116.ENSRNOP00000011697
IntAct ID Q00960
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24410
BindingDB Q00960

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.870 0.000 0.850 0.005 0.860 0.000 0.860 0.000 0.926 0.005 0.715 0.005 Download
Estate fingerprints 0.794 0.007 0.802 0.006 0.798 0.004 0.797 0.005 0.880 0.000 0.599 0.011 Download
MACCS fingerprints 0.827 0.005 0.797 0.007 0.812 0.004 0.816 0.005 0.890 0.000 0.624 0.007 Download
Daylight fingerprints 0.805 0.005 0.825 0.000 0.815 0.005 0.815 0.005 0.860 0.000 0.634 0.007 Download
ECFP2 fingerprints 0.891 0.006 0.929 0.005 0.910 0.000 0.909 0.003 0.960 0.000 0.820 0.005 Download
ECFP4 fingerprints 0.920 0.000 0.958 0.003 0.939 0.003 0.939 0.003 0.980 0.000 0.874 0.007 Download
ECFP6 fingerprints 0.906 0.005 0.986 0.000 0.946 0.005 0.944 0.005 0.970 0.000 0.895 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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