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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
| Uniprot primary ID | Q00975 |
| PDB ID | 2LCM |
| DrugBank ID | DB00661 DB00996 DB01202 DB00421 DB00381 |
| BioGrid ID | 107228 |
| GuidetoPHARMACOLOGY ID | 533 |
| PharmGKB ID | PA26008 |
| KEGG ID | hsa:774 |
| DIP ID | |
| STRING ID | 9606.ENSP00000360406 |
| IntAct ID | Q00975 |
| DMDM | 1705854 |
| BRENDA | |
| Reactome | R-HSA-112308 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 774 |
| BindingDB | Q00975 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.646 | 0.008 | 0.838 | 0.011 | 0.742 | 0.008 | 0.714 | 0.008 | 0.816 | 0.005 | 0.492 | 0.015 | Download |
| Estate fingerprints | 0.716 | 0.005 | 0.652 | 0.007 | 0.684 | 0.007 | 0.693 | 0.007 | 0.759 | 0.003 | 0.371 | 0.010 | Download |
| MACCS fingerprints | 0.694 | 0.008 | 0.776 | 0.011 | 0.735 | 0.010 | 0.723 | 0.008 | 0.802 | 0.004 | 0.468 | 0.014 | Download |
| Daylight fingerprints | 0.607 | 0.009 | 0.763 | 0.007 | 0.685 | 0.007 | 0.656 | 0.005 | 0.718 | 0.004 | 0.367 | 0.009 | Download |
| ECFP2 fingerprints | 0.676 | 0.008 | 0.872 | 0.008 | 0.774 | 0.005 | 0.749 | 0.006 | 0.863 | 0.005 | 0.560 | 0.011 | Download |
| ECFP4 fingerprints | 0.674 | 0.008 | 0.930 | 0.010 | 0.802 | 0.006 | 0.773 | 0.007 | 0.885 | 0.005 | 0.624 | 0.012 | Download |
| ECFP6 fingerprints | 0.607 | 0.008 | 0.949 | 0.005 | 0.778 | 0.004 | 0.733 | 0.007 | 0.871 | 0.003 | 0.596 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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