Target name

Q00975: Voltage-dependent N-type calcium channel subunit alpha-1B


  Protein function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

  Database links

Uniprot primary ID Q00975
PDB ID 2LCM
DrugBank ID DB00661 DB00996 DB01202 DB00421 DB00381
BioGrid ID 107228
GuidetoPHARMACOLOGY ID 533
PharmGKB ID PA26008
KEGG ID hsa:774
DIP ID
STRING ID 9606.ENSP00000360406
IntAct ID Q00975
DMDM 1705854
BRENDA
Reactome R-HSA-112308
SignaLink
BioCyc
Entrez Gene (Gene ID) 774
BindingDB Q00975

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.646 0.008 0.838 0.011 0.742 0.008 0.714 0.008 0.816 0.005 0.492 0.015 Download
Estate fingerprints 0.716 0.005 0.652 0.007 0.684 0.007 0.693 0.007 0.759 0.003 0.371 0.010 Download
MACCS fingerprints 0.694 0.008 0.776 0.011 0.735 0.010 0.723 0.008 0.802 0.004 0.468 0.014 Download
Daylight fingerprints 0.607 0.009 0.763 0.007 0.685 0.007 0.656 0.005 0.718 0.004 0.367 0.009 Download
ECFP2 fingerprints 0.676 0.008 0.872 0.008 0.774 0.005 0.749 0.006 0.863 0.005 0.560 0.011 Download
ECFP4 fingerprints 0.674 0.008 0.930 0.010 0.802 0.006 0.773 0.007 0.885 0.005 0.624 0.012 Download
ECFP6 fingerprints 0.607 0.008 0.949 0.005 0.778 0.004 0.733 0.007 0.871 0.003 0.596 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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