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E-mail: biomed@csu.edu.cn
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E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
| Uniprot primary ID | Q00987 |
| PDB ID | 1YCR 4QO4 3G03 3LNZ 3VBG 4OQ3 2MPS 3EQS 2C6B 2C6A 1T4F 1T4E 3TU1 4ZYC 4OGV 2FOP 4JVR 4ZYI 3LNJ 4OGN 3IUX 3VZV 3LBK 3TPX 1RV1 2LZG 4JV9 4HG7 2RUH 4UMN 2M86 4ERE 4DIJ 2HDP 4JV7 3MQS 4ZYF 2GV2 2AXI 2VJF 2F1Y 2VJE 4OCC 3JZK 3W69 4MDN 4MDQ 3IWY 4WT2 4OAS 4QOC |
| DrugBank ID | |
| BioGrid ID | 110358 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA30718 |
| KEGG ID | |
| DIP ID | DIP-392N |
| STRING ID | 9606.ENSP00000417281 |
| IntAct ID | Q00987 |
| DMDM | 266516 |
| BRENDA | 6.3.2.19 |
| Reactome | R-HSA-2559585 R-HSA-2559580 R-HSA-399719 R-HSA-5674400 R-HSA-69541 R-HSA-198323 |
| SignaLink | Q00987 |
| BioCyc | |
| Entrez Gene (Gene ID) | 4193 |
| BindingDB | Q00987 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.690 | 0.005 | 0.884 | 0.007 | 0.787 | 0.005 | 0.763 | 0.005 | 0.831 | 0.003 | 0.587 | 0.009 | Download |
| Estate fingerprints | 0.685 | 0.005 | 0.697 | 0.006 | 0.691 | 0.003 | 0.690 | 0.000 | 0.791 | 0.003 | 0.382 | 0.004 | Download |
| MACCS fingerprints | 0.747 | 0.007 | 0.795 | 0.008 | 0.771 | 0.003 | 0.768 | 0.004 | 0.840 | 0.000 | 0.548 | 0.004 | Download |
| Daylight fingerprints | 0.673 | 0.007 | 0.777 | 0.007 | 0.725 | 0.005 | 0.709 | 0.006 | 0.722 | 0.004 | 0.451 | 0.010 | Download |
| ECFP2 fingerprints | 0.751 | 0.007 | 0.917 | 0.008 | 0.834 | 0.005 | 0.818 | 0.006 | 0.889 | 0.003 | 0.678 | 0.014 | Download |
| ECFP4 fingerprints | 0.698 | 0.004 | 0.956 | 0.006 | 0.827 | 0.005 | 0.803 | 0.005 | 0.890 | 0.000 | 0.678 | 0.006 | Download |
| ECFP6 fingerprints | 0.684 | 0.005 | 0.972 | 0.005 | 0.828 | 0.004 | 0.798 | 0.004 | 0.893 | 0.005 | 0.687 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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