Target name

Q00987: E3 ubiquitin-protein ligase Mdm2


  Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.

  Database links

Uniprot primary ID Q00987
PDB ID 1YCR 4QO4 3G03 3LNZ 3VBG 4OQ3 2MPS 3EQS 2C6B 2C6A 1T4F 1T4E 3TU1 4ZYC 4OGV 2FOP 4JVR 4ZYI 3LNJ 4OGN 3IUX 3VZV 3LBK 3TPX 1RV1 2LZG 4JV9 4HG7 2RUH 4UMN 2M86 4ERE 4DIJ 2HDP 4JV7 3MQS 4ZYF 2GV2 2AXI 2VJF 2F1Y 2VJE 4OCC 3JZK 3W69 4MDN 4MDQ 3IWY 4WT2 4OAS 4QOC
DrugBank ID
BioGrid ID 110358
GuidetoPHARMACOLOGY ID
PharmGKB ID PA30718
KEGG ID
DIP ID DIP-392N
STRING ID 9606.ENSP00000417281
IntAct ID Q00987
DMDM 266516
BRENDA 6.3.2.19
Reactome R-HSA-2559585 R-HSA-2559580 R-HSA-399719 R-HSA-5674400 R-HSA-69541 R-HSA-198323
SignaLink Q00987
BioCyc
Entrez Gene (Gene ID) 4193
BindingDB Q00987

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.690 0.005 0.884 0.007 0.787 0.005 0.763 0.005 0.831 0.003 0.587 0.009 Download
Estate fingerprints 0.685 0.005 0.697 0.006 0.691 0.003 0.690 0.000 0.791 0.003 0.382 0.004 Download
MACCS fingerprints 0.747 0.007 0.795 0.008 0.771 0.003 0.768 0.004 0.840 0.000 0.548 0.004 Download
Daylight fingerprints 0.673 0.007 0.777 0.007 0.725 0.005 0.709 0.006 0.722 0.004 0.451 0.010 Download
ECFP2 fingerprints 0.751 0.007 0.917 0.008 0.834 0.005 0.818 0.006 0.889 0.003 0.678 0.014 Download
ECFP4 fingerprints 0.698 0.004 0.956 0.006 0.827 0.005 0.803 0.005 0.890 0.000 0.678 0.006 Download
ECFP6 fingerprints 0.684 0.005 0.972 0.005 0.828 0.004 0.798 0.004 0.893 0.005 0.687 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn