Target name

Q00G26: Perilipin-5


  Protein function

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).

  Database links

Uniprot primary ID Q00G26
PDB ID
DrugBank ID
BioGrid ID 136635
GuidetoPHARMACOLOGY ID
PharmGKB ID PA165394043
KEGG ID hsa:440503
DIP ID
STRING ID 9606.ENSP00000371272
IntAct ID
DMDM 292495026
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 440503
BindingDB Q00G26

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.616 0.013 0.920 0.007 0.768 0.009 0.728 0.009 0.869 0.003 0.563 0.015 Download
Estate fingerprints 0.756 0.005 0.766 0.008 0.761 0.006 0.758 0.006 0.839 0.003 0.520 0.009 Download
MACCS fingerprints 0.697 0.011 0.759 0.009 0.728 0.008 0.719 0.009 0.801 0.003 0.454 0.017 Download
Daylight fingerprints 0.393 0.013 0.953 0.013 0.673 0.007 0.546 0.012 0.776 0.013 0.419 0.020 Download
ECFP2 fingerprints 0.794 0.005 0.870 0.006 0.832 0.004 0.827 0.005 0.918 0.004 0.669 0.007 Download
ECFP4 fingerprints 0.738 0.008 0.904 0.006 0.821 0.007 0.804 0.005 0.900 0.000 0.649 0.010 Download
ECFP6 fingerprints 0.680 0.012 0.914 0.007 0.797 0.009 0.770 0.011 0.890 0.000 0.613 0.016 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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