Target name

Q02156: Protein kinase C epsilon type

  Protein function

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

  Database links

Uniprot primary ID Q02156
DrugBank ID DB00675
BioGrid ID 111567
PharmGKB ID PA33765
KEGG ID hsa:5581
STRING ID 9606.ENSP00000306124
IntAct ID Q02156
DMDM 400135
Reactome R-HSA-2029485 R-HSA-418597 R-HSA-114508 R-HSA-1489509
SignaLink Q02156
Entrez Gene (Gene ID) 5581
BindingDB Q02156

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.711 0.011 0.955 0.007 0.833 0.005 0.810 0.008 0.908 0.004 0.688 0.012 Download
Estate fingerprints 0.812 0.006 0.728 0.013 0.770 0.009 0.781 0.007 0.839 0.003 0.541 0.016 Download
MACCS fingerprints 0.843 0.008 0.771 0.010 0.807 0.009 0.813 0.008 0.870 0.000 0.614 0.017 Download
Daylight fingerprints 0.588 0.004 0.914 0.008 0.751 0.007 0.704 0.007 0.801 0.003 0.533 0.013 Download
ECFP2 fingerprints 0.882 0.006 0.882 0.005 0.882 0.004 0.882 0.004 0.955 0.005 0.764 0.005 Download
ECFP4 fingerprints 0.882 0.004 0.962 0.005 0.922 0.004 0.921 0.003 0.969 0.003 0.851 0.006 Download
ECFP6 fingerprints 0.839 0.011 0.977 0.000 0.908 0.006 0.901 0.007 0.961 0.003 0.825 0.008 Download

  Download datasets

Positive dataset Negative dataset

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