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E-mail: biomed@csu.edu.cn
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Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
| Uniprot primary ID | Q03181 |
| PDB ID | 2XYX 2XYW 3PEQ 2XYJ 2B50 2J14 2Q5G 2BAW 2ZNP 2ZNQ 1GWX 3ET2 3GWX 3GZ9 3TKM 3SP9 3DY6 3D5F 1Y0S 2GWX 2ENV 2AWH 3OZ0 |
| DrugBank ID | DB00159 DB01393 DB00605 DB00374 |
| BioGrid ID | 111463 |
| GuidetoPHARMACOLOGY ID | 594 |
| PharmGKB ID | PA33557 |
| KEGG ID | hsa:5467 |
| DIP ID | |
| STRING ID | 9606.ENSP00000310928 |
| IntAct ID | Q03181 |
| DMDM | 417522 |
| BRENDA | |
| Reactome | R-HSA-204174 R-HSA-383280 R-HSA-200425 R-HSA-5362517 |
| SignaLink | Q03181 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5467 |
| BindingDB | Q03181 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.878 | 0.004 | 0.956 | 0.003 | 0.917 | 0.005 | 0.910 | 0.000 | 0.970 | 0.000 | 0.832 | 0.004 | Download |
| Estate fingerprints | 0.900 | 0.000 | 0.896 | 0.005 | 0.898 | 0.004 | 0.899 | 0.003 | 0.960 | 0.000 | 0.790 | 0.000 | Download |
| MACCS fingerprints | 0.880 | 0.000 | 0.900 | 0.003 | 0.890 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.782 | 0.004 | Download |
| Daylight fingerprints | 0.870 | 0.000 | 0.938 | 0.000 | 0.904 | 0.005 | 0.900 | 0.000 | 0.950 | 0.000 | 0.811 | 0.003 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.960 | 0.003 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| ECFP4 fingerprints | 0.960 | 0.000 | 0.980 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.999 | 0.003 | 0.935 | 0.005 | Download |
| ECFP6 fingerprints | 0.941 | 0.003 | 0.985 | 0.003 | 0.963 | 0.005 | 0.961 | 0.003 | 0.990 | 0.000 | 0.930 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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