Target name

Q03181: Peroxisome proliferator-activated receptor delta


  Protein function

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

  Database links

Uniprot primary ID Q03181
PDB ID 2XYX 2XYW 3PEQ 2XYJ 2B50 2J14 2Q5G 2BAW 2ZNP 2ZNQ 1GWX 3ET2 3GWX 3GZ9 3TKM 3SP9 3DY6 3D5F 1Y0S 2GWX 2ENV 2AWH 3OZ0
DrugBank ID DB00159 DB01393 DB00605 DB00374
BioGrid ID 111463
GuidetoPHARMACOLOGY ID 594
PharmGKB ID PA33557
KEGG ID hsa:5467
DIP ID
STRING ID 9606.ENSP00000310928
IntAct ID Q03181
DMDM 417522
BRENDA
Reactome R-HSA-204174 R-HSA-383280 R-HSA-200425 R-HSA-5362517
SignaLink Q03181
BioCyc
Entrez Gene (Gene ID) 5467
BindingDB Q03181

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.878 0.004 0.956 0.003 0.917 0.005 0.910 0.000 0.970 0.000 0.832 0.004 Download
Estate fingerprints 0.900 0.000 0.896 0.005 0.898 0.004 0.899 0.003 0.960 0.000 0.790 0.000 Download
MACCS fingerprints 0.880 0.000 0.900 0.003 0.890 0.000 0.890 0.000 0.960 0.000 0.782 0.004 Download
Daylight fingerprints 0.870 0.000 0.938 0.000 0.904 0.005 0.900 0.000 0.950 0.000 0.811 0.003 Download
ECFP2 fingerprints 0.940 0.000 0.960 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.910 0.000 Download
ECFP4 fingerprints 0.960 0.000 0.980 0.000 0.970 0.000 0.970 0.000 0.999 0.003 0.935 0.005 Download
ECFP6 fingerprints 0.941 0.003 0.985 0.003 0.963 0.005 0.961 0.003 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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