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E-mail: biomed@csu.edu.cn
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Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
| Uniprot primary ID | Q04609 |
| PDB ID | 2XEI 4JYW 2XEJ 4MCP 4MCQ 4MCR 4MCS 2CIJ 2XEG 2XEF 4NGT 4W9Y 3BHX 2C6G 4NGS 4NGM 2C6C 4OME 4NGR 3D7D 1Z8L 3D7F 3D7G 4NGQ 3IWW 4NGP 3D7H 4P4D 4P4E 4P4F 3SJX 4P4B 4OC0 2OR4 3BI0 4P4I 3SJF 3SJG 4P44 4P45 2JBJ 2JBK 3BXM 4OC2 4OC3 4NGN 4OC1 4OC4 4OC5 3BI1 2C6P |
| DrugBank ID | DB00089 |
| BioGrid ID | 108630 |
| GuidetoPHARMACOLOGY ID | 1606 |
| PharmGKB ID | PA28205 |
| KEGG ID | hsa:2346 |
| DIP ID | |
| STRING ID | 9606.ENSP00000256999 |
| IntAct ID | Q04609 |
| DMDM | 548615 |
| BRENDA | 3.4.17.21 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2346 |
| BindingDB | Q04609 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.901 | 0.006 | 0.915 | 0.007 | 0.908 | 0.006 | 0.908 | 0.006 | 0.969 | 0.003 | 0.813 | 0.008 | Download |
| Estate fingerprints | 0.955 | 0.007 | 0.921 | 0.010 | 0.938 | 0.004 | 0.938 | 0.004 | 0.980 | 0.000 | 0.875 | 0.007 | Download |
| MACCS fingerprints | 0.927 | 0.005 | 0.933 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.857 | 0.005 | Download |
| Daylight fingerprints | 0.746 | 0.011 | 0.872 | 0.000 | 0.809 | 0.003 | 0.796 | 0.007 | 0.830 | 0.000 | 0.620 | 0.008 | Download |
| ECFP2 fingerprints | 0.996 | 0.005 | 0.952 | 0.007 | 0.974 | 0.005 | 0.974 | 0.005 | 1.000 | 0.000 | 0.947 | 0.005 | Download |
| ECFP4 fingerprints | 0.997 | 0.005 | 0.977 | 0.000 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.976 | 0.007 | Download |
| ECFP6 fingerprints | 0.999 | 0.003 | 0.979 | 0.000 | 0.989 | 0.003 | 0.989 | 0.003 | 1.000 | 0.000 | 0.979 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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