Target name

Q04609: Glutamate carboxypeptidase 2


  Protein function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.

  Database links

Uniprot primary ID Q04609
PDB ID 2XEI 4JYW 2XEJ 4MCP 4MCQ 4MCR 4MCS 2CIJ 2XEG 2XEF 4NGT 4W9Y 3BHX 2C6G 4NGS 4NGM 2C6C 4OME 4NGR 3D7D 1Z8L 3D7F 3D7G 4NGQ 3IWW 4NGP 3D7H 4P4D 4P4E 4P4F 3SJX 4P4B 4OC0 2OR4 3BI0 4P4I 3SJF 3SJG 4P44 4P45 2JBJ 2JBK 3BXM 4OC2 4OC3 4NGN 4OC1 4OC4 4OC5 3BI1 2C6P
DrugBank ID DB00089
BioGrid ID 108630
GuidetoPHARMACOLOGY ID 1606
PharmGKB ID PA28205
KEGG ID hsa:2346
DIP ID
STRING ID 9606.ENSP00000256999
IntAct ID Q04609
DMDM 548615
BRENDA 3.4.17.21
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 2346
BindingDB Q04609

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.901 0.006 0.915 0.007 0.908 0.006 0.908 0.006 0.969 0.003 0.813 0.008 Download
Estate fingerprints 0.955 0.007 0.921 0.010 0.938 0.004 0.938 0.004 0.980 0.000 0.875 0.007 Download
MACCS fingerprints 0.927 0.005 0.933 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.857 0.005 Download
Daylight fingerprints 0.746 0.011 0.872 0.000 0.809 0.003 0.796 0.007 0.830 0.000 0.620 0.008 Download
ECFP2 fingerprints 0.996 0.005 0.952 0.007 0.974 0.005 0.974 0.005 1.000 0.000 0.947 0.005 Download
ECFP4 fingerprints 0.997 0.005 0.977 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.976 0.007 Download
ECFP6 fingerprints 0.999 0.003 0.979 0.000 0.989 0.003 0.989 0.003 1.000 0.000 0.979 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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