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E-mail: biomed@csu.edu.cn
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Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
| Uniprot primary ID | Q04631 |
| PDB ID | 4GTO 4GTM 1FTI 1JCR 1JCS 2ZIS 2ZIR 1HZ7 1SA5 1QBQ 1FPP 4GTQ 4GTP 2FTI 1TN7 3KSL 1O5M 2BED 1TN8 1NI1 2R2L 1D8E 1D8D 1O1S 1O1R 1N94 1N95 1O1T 1TNU 3E30 3E33 3E32 3E34 3DPY 1TNY 1N9A 3FTI 1TNB 1TNO 1TNZ 3KSQ 1KZR 1NL4 1KZP 3EUV 4GTR 1S64 3EU5 1FT1 1KZO 1X81 |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | rno:25318 |
| DIP ID | DIP-6131N |
| STRING ID | 10116.ENSRNOP00000019594 |
| IntAct ID | Q04631 |
| DMDM | |
| BRENDA | 2.5.1.58 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25318 |
| BindingDB | Q04631 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.924 | 0.005 | 0.914 | 0.009 | 0.919 | 0.003 | 0.919 | 0.003 | 0.970 | 0.000 | 0.833 | 0.007 | Download |
| Estate fingerprints | 0.835 | 0.010 | 0.861 | 0.008 | 0.848 | 0.006 | 0.845 | 0.005 | 0.908 | 0.004 | 0.697 | 0.011 | Download |
| MACCS fingerprints | 0.836 | 0.008 | 0.842 | 0.003 | 0.839 | 0.006 | 0.839 | 0.006 | 0.920 | 0.000 | 0.676 | 0.012 | Download |
| Daylight fingerprints | 0.863 | 0.005 | 0.917 | 0.003 | 0.890 | 0.005 | 0.888 | 0.004 | 0.919 | 0.003 | 0.781 | 0.007 | Download |
| ECFP2 fingerprints | 0.952 | 0.004 | 0.976 | 0.006 | 0.964 | 0.005 | 0.964 | 0.005 | 0.986 | 0.005 | 0.925 | 0.005 | Download |
| ECFP4 fingerprints | 0.949 | 0.003 | 0.985 | 0.004 | 0.967 | 0.005 | 0.967 | 0.005 | 0.989 | 0.003 | 0.931 | 0.006 | Download |
| ECFP6 fingerprints | 0.912 | 0.008 | 0.990 | 0.000 | 0.951 | 0.006 | 0.951 | 0.006 | 0.989 | 0.003 | 0.909 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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