Target name

Q04631: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


  Protein function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

  Database links

Uniprot primary ID Q04631
PDB ID 4GTO 4GTM 1FTI 1JCR 1JCS 2ZIS 2ZIR 1HZ7 1SA5 1QBQ 1FPP 4GTQ 4GTP 2FTI 1TN7 3KSL 1O5M 2BED 1TN8 1NI1 2R2L 1D8E 1D8D 1O1S 1O1R 1N94 1N95 1O1T 1TNU 3E30 3E33 3E32 3E34 3DPY 1TNY 1N9A 3FTI 1TNB 1TNO 1TNZ 3KSQ 1KZR 1NL4 1KZP 3EUV 4GTR 1S64 3EU5 1FT1 1KZO 1X81
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:25318
DIP ID DIP-6131N
STRING ID 10116.ENSRNOP00000019594
IntAct ID Q04631
DMDM
BRENDA 2.5.1.58
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25318
BindingDB Q04631

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.924 0.005 0.914 0.009 0.919 0.003 0.919 0.003 0.970 0.000 0.833 0.007 Download
Estate fingerprints 0.835 0.010 0.861 0.008 0.848 0.006 0.845 0.005 0.908 0.004 0.697 0.011 Download
MACCS fingerprints 0.836 0.008 0.842 0.003 0.839 0.006 0.839 0.006 0.920 0.000 0.676 0.012 Download
Daylight fingerprints 0.863 0.005 0.917 0.003 0.890 0.005 0.888 0.004 0.919 0.003 0.781 0.007 Download
ECFP2 fingerprints 0.952 0.004 0.976 0.006 0.964 0.005 0.964 0.005 0.986 0.005 0.925 0.005 Download
ECFP4 fingerprints 0.949 0.003 0.985 0.004 0.967 0.005 0.967 0.005 0.989 0.003 0.931 0.006 Download
ECFP6 fingerprints 0.912 0.008 0.990 0.000 0.951 0.006 0.951 0.006 0.989 0.003 0.909 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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