In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
| Uniprot primary ID | Q05469 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 110179 |
| GuidetoPHARMACOLOGY ID | 2593 |
| PharmGKB ID | PA30393 |
| KEGG ID | hsa:3991 |
| DIP ID | |
| STRING ID | 9606.ENSP00000244289 |
| IntAct ID | Q05469 |
| DMDM | 145559491 |
| BRENDA | 3.1.1.79 |
| Reactome | R-HSA-163560 |
| SignaLink | |
| BioCyc | MetaCyc:HS01328-MONOMER |
| Entrez Gene (Gene ID) | 3991 |
| BindingDB | Q05469 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.898 | 0.004 | 0.992 | 0.003 | 0.945 | 0.005 | 0.940 | 0.000 | 0.990 | 0.000 | 0.895 | 0.005 | Download |
| Estate fingerprints | 0.976 | 0.007 | 0.862 | 0.005 | 0.919 | 0.003 | 0.923 | 0.005 | 0.970 | 0.000 | 0.845 | 0.007 | Download |
| MACCS fingerprints | 0.960 | 0.005 | 0.884 | 0.010 | 0.922 | 0.006 | 0.924 | 0.005 | 0.980 | 0.000 | 0.848 | 0.012 | Download |
| Daylight fingerprints | 0.830 | 0.007 | 1.000 | 0.000 | 0.917 | 0.005 | 0.908 | 0.004 | 0.980 | 0.000 | 0.842 | 0.004 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.958 | 0.000 | 0.974 | 0.005 | 0.974 | 0.005 | 1.000 | 0.000 | 0.949 | 0.006 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.990 | 0.004 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.982 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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