Target name

Q05469: Hormone-sensitive lipase


  Protein function

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

  Database links

Uniprot primary ID Q05469
PDB ID
DrugBank ID
BioGrid ID 110179
GuidetoPHARMACOLOGY ID 2593
PharmGKB ID PA30393
KEGG ID hsa:3991
DIP ID
STRING ID 9606.ENSP00000244289
IntAct ID Q05469
DMDM 145559491
BRENDA 3.1.1.79
Reactome R-HSA-163560
SignaLink
BioCyc MetaCyc:HS01328-MONOMER
Entrez Gene (Gene ID) 3991
BindingDB Q05469

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.898 0.004 0.992 0.003 0.945 0.005 0.940 0.000 0.990 0.000 0.895 0.005 Download
Estate fingerprints 0.976 0.007 0.862 0.005 0.919 0.003 0.923 0.005 0.970 0.000 0.845 0.007 Download
MACCS fingerprints 0.960 0.005 0.884 0.010 0.922 0.006 0.924 0.005 0.980 0.000 0.848 0.012 Download
Daylight fingerprints 0.830 0.007 1.000 0.000 0.917 0.005 0.908 0.004 0.980 0.000 0.842 0.004 Download
ECFP2 fingerprints 0.990 0.000 0.958 0.000 0.974 0.005 0.974 0.005 1.000 0.000 0.949 0.006 Download
ECFP4 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP6 fingerprints 0.990 0.000 0.990 0.004 0.990 0.000 0.990 0.000 1.000 0.000 0.982 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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