Target name

Q05769: Prostaglandin G/H synthase 2


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

  Database links

Uniprot primary ID Q05769
PDB ID 3NT1 3Q7D 1DCX 4E1G 3RR3 3PGH 3MDL 4RUT 1PXX 4M10 4M11 3QMO 1DD0 4FM5 4PH9 3TZI 1DDX 3NTB 3QH0 3MQE 4OTJ 5COX 3HS5 3HS6 1CVU 1CX2 6COX 4OTY 4RS0 3KRK 3LN1 3LN0 4COX 4Z0L 3NTG 3HS7 4RRX 4RRY 4RRZ 3OLU 3OLT 4RRW
DrugBank ID
BioGrid ID 202463
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:19225
DIP ID DIP-31082N
STRING ID 10090.ENSMUSP00000035065
IntAct ID Q05769
DMDM
BRENDA 1.14.99.1
Reactome R-MMU-197264 R-MMU-2142770 R-MMU-2162123
SignaLink
BioCyc
Entrez Gene (Gene ID) 19225
BindingDB Q05769

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.858 0.009 0.962 0.005 0.910 0.005 0.906 0.005 0.980 0.000 0.825 0.007 Download
Estate fingerprints 0.767 0.007 0.809 0.004 0.788 0.006 0.786 0.005 0.888 0.004 0.577 0.012 Download
MACCS fingerprints 0.796 0.007 0.800 0.005 0.798 0.004 0.798 0.004 0.890 0.000 0.597 0.005 Download
Daylight fingerprints 0.694 0.008 0.972 0.004 0.833 0.007 0.807 0.007 0.932 0.004 0.696 0.008 Download
ECFP2 fingerprints 0.921 0.003 0.921 0.005 0.921 0.003 0.921 0.003 0.970 0.000 0.845 0.008 Download
ECFP4 fingerprints 0.939 0.007 0.947 0.005 0.943 0.005 0.943 0.005 0.980 0.000 0.890 0.007 Download
ECFP6 fingerprints 0.922 0.006 0.968 0.005 0.945 0.005 0.944 0.005 0.980 0.000 0.891 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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