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E-mail: biomed@csu.edu.cn
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Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
| Uniprot primary ID | Q05769 |
| PDB ID | 3NT1 3Q7D 1DCX 4E1G 3RR3 3PGH 3MDL 4RUT 1PXX 4M10 4M11 3QMO 1DD0 4FM5 4PH9 3TZI 1DDX 3NTB 3QH0 3MQE 4OTJ 5COX 3HS5 3HS6 1CVU 1CX2 6COX 4OTY 4RS0 3KRK 3LN1 3LN0 4COX 4Z0L 3NTG 3HS7 4RRX 4RRY 4RRZ 3OLU 3OLT 4RRW |
| DrugBank ID | |
| BioGrid ID | 202463 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | mmu:19225 |
| DIP ID | DIP-31082N |
| STRING ID | 10090.ENSMUSP00000035065 |
| IntAct ID | Q05769 |
| DMDM | |
| BRENDA | 1.14.99.1 |
| Reactome | R-MMU-197264 R-MMU-2142770 R-MMU-2162123 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 19225 |
| BindingDB | Q05769 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.858 | 0.009 | 0.962 | 0.005 | 0.910 | 0.005 | 0.906 | 0.005 | 0.980 | 0.000 | 0.825 | 0.007 | Download |
| Estate fingerprints | 0.767 | 0.007 | 0.809 | 0.004 | 0.788 | 0.006 | 0.786 | 0.005 | 0.888 | 0.004 | 0.577 | 0.012 | Download |
| MACCS fingerprints | 0.796 | 0.007 | 0.800 | 0.005 | 0.798 | 0.004 | 0.798 | 0.004 | 0.890 | 0.000 | 0.597 | 0.005 | Download |
| Daylight fingerprints | 0.694 | 0.008 | 0.972 | 0.004 | 0.833 | 0.007 | 0.807 | 0.007 | 0.932 | 0.004 | 0.696 | 0.008 | Download |
| ECFP2 fingerprints | 0.921 | 0.003 | 0.921 | 0.005 | 0.921 | 0.003 | 0.921 | 0.003 | 0.970 | 0.000 | 0.845 | 0.008 | Download |
| ECFP4 fingerprints | 0.939 | 0.007 | 0.947 | 0.005 | 0.943 | 0.005 | 0.943 | 0.005 | 0.980 | 0.000 | 0.890 | 0.007 | Download |
| ECFP6 fingerprints | 0.922 | 0.006 | 0.968 | 0.005 | 0.945 | 0.005 | 0.944 | 0.005 | 0.980 | 0.000 | 0.891 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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