Target name

Q05941: Neuronal acetylcholine receptor subunit alpha-7


  Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

  Database links

Uniprot primary ID Q05941
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 468
PharmGKB ID
KEGG ID rno:25302
DIP ID
STRING ID 10116.ENSRNOP00000045255
IntAct ID Q05941
DMDM
BRENDA
Reactome R-RNO-629594
SignaLink
BioCyc
Entrez Gene (Gene ID) 25302
BindingDB Q05941

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.931 0.003 0.891 0.004 0.911 0.003 0.912 0.004 0.970 0.000 0.824 0.005 Download
Estate fingerprints 0.867 0.007 0.775 0.000 0.821 0.006 0.828 0.004 0.900 0.000 0.646 0.010 Download
MACCS fingerprints 0.903 0.005 0.773 0.000 0.838 0.004 0.848 0.004 0.910 0.000 0.681 0.006 Download
Daylight fingerprints 0.840 0.005 0.800 0.005 0.820 0.000 0.823 0.005 0.860 0.000 0.643 0.005 Download
ECFP2 fingerprints 0.920 0.000 0.922 0.000 0.921 0.003 0.920 0.000 0.980 0.000 0.843 0.005 Download
ECFP4 fingerprints 0.930 0.000 0.986 0.000 0.958 0.004 0.956 0.005 0.990 0.000 0.915 0.005 Download
ECFP6 fingerprints 0.917 0.005 0.983 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.904 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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