Target name

Q06418: Tyrosine-protein kinase receptor TYRO3


  Protein function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

  Database links

Uniprot primary ID Q06418
PDB ID 1RHF
DrugBank ID
BioGrid ID 113152
GuidetoPHARMACOLOGY ID 1836
PharmGKB ID PA37097
KEGG ID hsa:7301
DIP ID
STRING ID 9606.ENSP00000263798
IntAct ID Q06418
DMDM 1717829
BRENDA 2.7.10.1
Reactome
SignaLink Q06418
BioCyc
Entrez Gene (Gene ID) 7301
BindingDB Q06418

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.007 0.958 0.006 0.904 0.005 0.899 0.003 0.942 0.004 0.815 0.005 Download
Estate fingerprints 0.835 0.011 0.809 0.013 0.822 0.006 0.823 0.007 0.885 0.005 0.641 0.011 Download
MACCS fingerprints 0.864 0.010 0.830 0.005 0.847 0.008 0.848 0.006 0.949 0.003 0.691 0.015 Download
Daylight fingerprints 0.805 0.008 0.971 0.007 0.888 0.006 0.879 0.006 0.950 0.000 0.793 0.011 Download
ECFP2 fingerprints 0.855 0.007 0.947 0.005 0.901 0.003 0.900 0.000 0.957 0.005 0.811 0.003 Download
ECFP4 fingerprints 0.860 0.009 0.988 0.000 0.924 0.005 0.917 0.007 0.975 0.005 0.857 0.007 Download
ECFP6 fingerprints 0.840 0.007 0.996 0.000 0.918 0.004 0.910 0.000 0.965 0.007 0.842 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn