Target name

Q07343: cAMP-specific 3',5'-cyclic phosphodiesterase 4B


  Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

  Database links

Uniprot primary ID Q07343
PDB ID 1RO6 3HC8 4NW7 1RO9 3O57 3O56 3O0J 1XLZ 1XLX 3KKT 2QYL 1TB5 4X0F 3GWT 3D3P 1XM4 3HDZ 3LY2 1XM6 1Y2H 1Y2J 4KP6 1XMU 1XMY 1XOT 3W5E 1XOS 1F0J 1JP1 1JP2 3HMV 4MYQ 2CHM 3FRG 1ROR 3WD9 1XN0 3G45 4WZI
DrugBank ID DB00131 DB01088 DB01427 DB00651 DB00920 DB01113 DB05266
BioGrid ID 111168
GuidetoPHARMACOLOGY ID 1301
PharmGKB ID PA33129
KEGG ID hsa:5142
DIP ID
STRING ID 9606.ENSP00000332116
IntAct ID Q07343
DMDM 729163
BRENDA 3.1.4.53
Reactome R-HSA-180024 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5142
BindingDB Q07343

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.845 0.005 0.911 0.003 0.878 0.004 0.872 0.004 0.950 0.000 0.754 0.005 Download
Estate fingerprints 0.717 0.007 0.743 0.003 0.730 0.005 0.725 0.005 0.820 0.000 0.460 0.008 Download
MACCS fingerprints 0.804 0.005 0.770 0.004 0.787 0.005 0.790 0.005 0.860 0.000 0.576 0.008 Download
Daylight fingerprints 0.821 0.003 0.759 0.000 0.790 0.000 0.791 0.003 0.835 0.005 0.578 0.004 Download
ECFP2 fingerprints 0.927 0.005 0.915 0.003 0.921 0.003 0.921 0.003 0.980 0.000 0.843 0.007 Download
ECFP4 fingerprints 0.942 0.004 0.978 0.003 0.960 0.000 0.957 0.005 0.987 0.005 0.915 0.005 Download
ECFP6 fingerprints 0.928 0.004 0.990 0.005 0.959 0.003 0.958 0.004 0.981 0.003 0.918 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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