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E-mail: biomed@csu.edu.cn
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Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
| Uniprot primary ID | Q07817 |
| PDB ID | 2ME8 2ME9 3FDM 3FDL 3ZLO 3ZLN 2O2N 3IO8 1BXL 3CVA 4C52 4BPK 1G5J 3ZLR 4EHR 2P1L 4IEH 4AQ3 2LP8 4PPI 3SPF 4TUH 3INQ 2O1Y 3ZK6 3PL7 3WIZ 2YJ1 2YQ6 2YQ7 2LPC 1MAZ 1R2G 4QVF 4QVE 2M04 2M03 4HNJ 3SP7 4QVX 2PON 1R2I 1R2H 4A1W 1LXL 4A1U 2B48 1YSG 2YXJ 1R2E 2O2M |
| DrugBank ID | |
| BioGrid ID | 107070 |
| GuidetoPHARMACOLOGY ID | 2845 |
| PharmGKB ID | PA76 |
| KEGG ID | hsa:598 |
| DIP ID | DIP-30916N |
| STRING ID | 9606.ENSP00000302564 |
| IntAct ID | Q07817 |
| DMDM | 728955 |
| BRENDA | |
| Reactome | R-HSA-844455 R-HSA-111453 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 598 |
| BindingDB | Q07817 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.711 | 0.007 | 0.983 | 0.000 | 0.847 | 0.005 | 0.822 | 0.006 | 0.911 | 0.003 | 0.720 | 0.005 | Download |
| Estate fingerprints | 0.740 | 0.005 | 0.808 | 0.005 | 0.774 | 0.005 | 0.764 | 0.005 | 0.860 | 0.000 | 0.544 | 0.005 | Download |
| MACCS fingerprints | 0.660 | 0.000 | 0.840 | 0.005 | 0.750 | 0.000 | 0.725 | 0.005 | 0.870 | 0.000 | 0.505 | 0.005 | Download |
| Daylight fingerprints | 0.679 | 0.003 | 0.867 | 0.003 | 0.773 | 0.005 | 0.751 | 0.003 | 0.819 | 0.003 | 0.559 | 0.006 | Download |
| ECFP2 fingerprints | 0.790 | 0.008 | 0.980 | 0.000 | 0.885 | 0.005 | 0.874 | 0.005 | 0.960 | 0.000 | 0.787 | 0.008 | Download |
| ECFP4 fingerprints | 0.769 | 0.006 | 0.989 | 0.000 | 0.879 | 0.003 | 0.864 | 0.005 | 0.970 | 0.000 | 0.778 | 0.004 | Download |
| ECFP6 fingerprints | 0.728 | 0.004 | 0.992 | 0.003 | 0.860 | 0.000 | 0.840 | 0.000 | 0.975 | 0.005 | 0.753 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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