Target name

Q07817: Bcl-2-like protein 1


  Protein function

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

  Database links

Uniprot primary ID Q07817
PDB ID 2ME8 2ME9 3FDM 3FDL 3ZLO 3ZLN 2O2N 3IO8 1BXL 3CVA 4C52 4BPK 1G5J 3ZLR 4EHR 2P1L 4IEH 4AQ3 2LP8 4PPI 3SPF 4TUH 3INQ 2O1Y 3ZK6 3PL7 3WIZ 2YJ1 2YQ6 2YQ7 2LPC 1MAZ 1R2G 4QVF 4QVE 2M04 2M03 4HNJ 3SP7 4QVX 2PON 1R2I 1R2H 4A1W 1LXL 4A1U 2B48 1YSG 2YXJ 1R2E 2O2M
DrugBank ID
BioGrid ID 107070
GuidetoPHARMACOLOGY ID 2845
PharmGKB ID PA76
KEGG ID hsa:598
DIP ID DIP-30916N
STRING ID 9606.ENSP00000302564
IntAct ID Q07817
DMDM 728955
BRENDA
Reactome R-HSA-844455 R-HSA-111453
SignaLink
BioCyc
Entrez Gene (Gene ID) 598
BindingDB Q07817

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.711 0.007 0.983 0.000 0.847 0.005 0.822 0.006 0.911 0.003 0.720 0.005 Download
Estate fingerprints 0.740 0.005 0.808 0.005 0.774 0.005 0.764 0.005 0.860 0.000 0.544 0.005 Download
MACCS fingerprints 0.660 0.000 0.840 0.005 0.750 0.000 0.725 0.005 0.870 0.000 0.505 0.005 Download
Daylight fingerprints 0.679 0.003 0.867 0.003 0.773 0.005 0.751 0.003 0.819 0.003 0.559 0.006 Download
ECFP2 fingerprints 0.790 0.008 0.980 0.000 0.885 0.005 0.874 0.005 0.960 0.000 0.787 0.008 Download
ECFP4 fingerprints 0.769 0.006 0.989 0.000 0.879 0.003 0.864 0.005 0.970 0.000 0.778 0.004 Download
ECFP6 fingerprints 0.728 0.004 0.992 0.003 0.860 0.000 0.840 0.000 0.975 0.005 0.753 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn