Target name

Q07820: Induced myeloid leukemia cell differentiation protein Mcl-1


  Protein function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

  Database links

Uniprot primary ID Q07820
PDB ID 3IO9 3PK1 2PQK 3KJ1 2NLA 4OQ6 4BPJ 4WMR 4BPI 4WMT 4WMU 4WMV 4WMW 4WMX 3MK8 4HW4 2KBW 3D7V 3WIY 3WIX 4OQ5 3KJ0 3TWU 3KJ2 2MHS 3KZ0 2NL9 4ZBF 4WMS 4HW3 4HW2 4ZBI 4WGI
DrugBank ID
BioGrid ID 110338
GuidetoPHARMACOLOGY ID 2847
PharmGKB ID PA30688
KEGG ID hsa:4170
DIP ID DIP-231N
STRING ID 9606.ENSP00000358022
IntAct ID Q07820
DMDM 83304396
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 4170
BindingDB Q07820

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.748 0.012 0.924 0.005 0.836 0.007 0.817 0.008 0.910 0.000 0.682 0.010 Download
Estate fingerprints 0.797 0.008 0.795 0.007 0.796 0.007 0.796 0.007 0.885 0.005 0.594 0.012 Download
MACCS fingerprints 0.744 0.008 0.790 0.008 0.767 0.005 0.763 0.005 0.831 0.003 0.536 0.008 Download
Daylight fingerprints 0.717 0.007 0.887 0.007 0.802 0.004 0.784 0.005 0.835 0.005 0.613 0.009 Download
ECFP2 fingerprints 0.863 0.007 0.837 0.005 0.850 0.005 0.854 0.005 0.937 0.005 0.704 0.008 Download
ECFP4 fingerprints 0.828 0.009 0.890 0.013 0.859 0.009 0.855 0.010 0.930 0.000 0.720 0.016 Download
ECFP6 fingerprints 0.744 0.007 0.954 0.007 0.849 0.003 0.830 0.005 0.920 0.000 0.711 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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