Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Uniprot primary ID | Q07912 |
PDB ID | 1U46 4ID7 4HZR 1U54 1CF4 1U4D 4EWH 3EQR 3EQP 4HZS |
DrugBank ID | DB00171 |
BioGrid ID | 115485 |
GuidetoPHARMACOLOGY ID | 2246 |
PharmGKB ID | PA134909759 |
KEGG ID | hsa:10188 |
DIP ID | DIP-33858N |
STRING ID | 9606.ENSP00000371341 |
IntAct ID | Q07912 |
DMDM | 229462980 |
BRENDA | 2.7.10.2 |
Reactome | |
SignaLink | Q07912 |
BioCyc | |
Entrez Gene (Gene ID) | 10188 |
BindingDB | Q07912 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.875 | 0.007 | 0.983 | 0.000 | 0.929 | 0.003 | 0.928 | 0.004 | 0.970 | 0.000 | 0.865 | 0.007 | Download |
Estate fingerprints | 0.892 | 0.004 | 0.858 | 0.004 | 0.875 | 0.005 | 0.878 | 0.004 | 0.940 | 0.000 | 0.748 | 0.004 | Download |
MACCS fingerprints | 0.909 | 0.003 | 0.907 | 0.003 | 0.908 | 0.004 | 0.908 | 0.004 | 0.962 | 0.004 | 0.812 | 0.004 | Download |
Daylight fingerprints | 0.811 | 0.006 | 0.991 | 0.005 | 0.901 | 0.003 | 0.890 | 0.005 | 0.970 | 0.000 | 0.818 | 0.004 | Download |
ECFP2 fingerprints | 0.920 | 0.000 | 0.980 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.980 | 0.000 | 0.903 | 0.005 | Download |
ECFP4 fingerprints | 0.930 | 0.000 | 1.000 | 0.000 | 0.967 | 0.005 | 0.960 | 0.000 | 0.980 | 0.000 | 0.930 | 0.000 | Download |
ECFP6 fingerprints | 0.930 | 0.000 | 1.000 | 0.000 | 0.968 | 0.004 | 0.960 | 0.000 | 0.977 | 0.005 | 0.930 | 0.000 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn