Target name

Q07912: Activated CDC42 kinase 1


  Protein function

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

  Database links

Uniprot primary ID Q07912
PDB ID 1U46 4ID7 4HZR 1U54 1CF4 1U4D 4EWH 3EQR 3EQP 4HZS
DrugBank ID DB00171
BioGrid ID 115485
GuidetoPHARMACOLOGY ID 2246
PharmGKB ID PA134909759
KEGG ID hsa:10188
DIP ID DIP-33858N
STRING ID 9606.ENSP00000371341
IntAct ID Q07912
DMDM 229462980
BRENDA 2.7.10.2
Reactome
SignaLink Q07912
BioCyc
Entrez Gene (Gene ID) 10188
BindingDB Q07912

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.875 0.007 0.983 0.000 0.929 0.003 0.928 0.004 0.970 0.000 0.865 0.007 Download
Estate fingerprints 0.892 0.004 0.858 0.004 0.875 0.005 0.878 0.004 0.940 0.000 0.748 0.004 Download
MACCS fingerprints 0.909 0.003 0.907 0.003 0.908 0.004 0.908 0.004 0.962 0.004 0.812 0.004 Download
Daylight fingerprints 0.811 0.006 0.991 0.005 0.901 0.003 0.890 0.005 0.970 0.000 0.818 0.004 Download
ECFP2 fingerprints 0.920 0.000 0.980 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.903 0.005 Download
ECFP4 fingerprints 0.930 0.000 1.000 0.000 0.967 0.005 0.960 0.000 0.980 0.000 0.930 0.000 Download
ECFP6 fingerprints 0.930 0.000 1.000 0.000 0.968 0.004 0.960 0.000 0.977 0.005 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn