Target name

Q08499: cAMP-specific 3',5'-cyclic phosphodiesterase 4D


  Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

  Database links

Uniprot primary ID Q08499
PDB ID 3G4L 3G4K 3G4I 3G4G 1TBB 1Y2C 1PTW 2FM5 1XOR 2FM0 1OYN 2QYN 3G58 1MKD 1Q9M 1TB7 3V9B 4OGB 1XON 3SL3 1Y2B 1XOM 1Y2D 1Y2E 3SL4 3SL5 3SL6 3SL8 1Y2K 3K4S 3IAD 3IAK 1XOQ 4WCU 2PW3 1ZKN 4W1O 1E9K
DrugBank ID DB00131 DB01088 DB00651 DB00920 DB05266 DB01656 DB00201
BioGrid ID 111170
GuidetoPHARMACOLOGY ID 1303
PharmGKB ID PA33130
KEGG ID hsa:5144
DIP ID DIP-41115N;DIP-29709N
STRING ID 9606.ENSP00000345502
IntAct ID Q08499
DMDM 12644392
BRENDA 3.1.4.53
Reactome R-HSA-180024 R-HSA-418555
SignaLink Q08499
BioCyc
Entrez Gene (Gene ID) 5144
BindingDB Q08499

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.845 0.007 0.887 0.008 0.866 0.007 0.863 0.005 0.933 0.005 0.734 0.011 Download
Estate fingerprints 0.707 0.009 0.719 0.005 0.713 0.008 0.709 0.009 0.789 0.003 0.424 0.012 Download
MACCS fingerprints 0.737 0.007 0.777 0.005 0.757 0.005 0.750 0.005 0.836 0.005 0.514 0.008 Download
Daylight fingerprints 0.801 0.003 0.849 0.004 0.825 0.005 0.821 0.003 0.864 0.005 0.655 0.008 Download
ECFP2 fingerprints 0.952 0.006 0.890 0.005 0.921 0.006 0.924 0.005 0.970 0.000 0.845 0.008 Download
ECFP4 fingerprints 0.930 0.005 0.962 0.004 0.946 0.005 0.944 0.005 0.977 0.005 0.893 0.005 Download
ECFP6 fingerprints 0.897 0.005 0.979 0.005 0.938 0.004 0.933 0.005 0.980 0.000 0.874 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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