Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
| Uniprot primary ID | Q13093 |
| PDB ID | 3D5E 3F9C 3F98 3D59 3F96 3F97 |
| DrugBank ID | |
| BioGrid ID | 113667 |
| GuidetoPHARMACOLOGY ID | 1432 |
| PharmGKB ID | PA33368 |
| KEGG ID | hsa:7941 |
| DIP ID | |
| STRING ID | 9606.ENSP00000274793 |
| IntAct ID | Q13093 |
| DMDM | 2497687 |
| BRENDA | 3.1.1.47 3.1.1.4 |
| Reactome | R-HSA-422085 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 7941 |
| BindingDB | Q13093 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.795 | 0.005 | 1.000 | 0.000 | 0.898 | 0.004 | 0.885 | 0.005 | 0.990 | 0.000 | 0.808 | 0.004 | Download |
| Estate fingerprints | 0.876 | 0.005 | 0.940 | 0.000 | 0.908 | 0.004 | 0.900 | 0.000 | 0.960 | 0.000 | 0.813 | 0.005 | Download |
| MACCS fingerprints | 0.854 | 0.007 | 0.970 | 0.004 | 0.912 | 0.006 | 0.906 | 0.005 | 0.960 | 0.000 | 0.828 | 0.010 | Download |
| Daylight fingerprints | 0.680 | 0.000 | 1.000 | 0.000 | 0.840 | 0.000 | 0.810 | 0.000 | 0.999 | 0.003 | 0.720 | 0.000 | Download |
| ECFP2 fingerprints | 0.908 | 0.004 | 0.988 | 0.004 | 0.948 | 0.004 | 0.944 | 0.005 | 0.990 | 0.000 | 0.898 | 0.004 | Download |
| ECFP4 fingerprints | 0.968 | 0.004 | 0.998 | 0.000 | 0.983 | 0.005 | 0.983 | 0.005 | 1.000 | 0.000 | 0.968 | 0.004 | Download |
| ECFP6 fingerprints | 0.975 | 0.007 | 1.000 | 0.000 | 0.989 | 0.003 | 0.989 | 0.003 | 1.000 | 0.000 | 0.975 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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