Target name

Q13093: Platelet-activating factor acetylhydrolase


  Protein function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

  Database links

Uniprot primary ID Q13093
PDB ID 3D5E 3F9C 3F98 3D59 3F96 3F97
DrugBank ID
BioGrid ID 113667
GuidetoPHARMACOLOGY ID 1432
PharmGKB ID PA33368
KEGG ID hsa:7941
DIP ID
STRING ID 9606.ENSP00000274793
IntAct ID Q13093
DMDM 2497687
BRENDA 3.1.1.47 3.1.1.4
Reactome R-HSA-422085
SignaLink
BioCyc
Entrez Gene (Gene ID) 7941
BindingDB Q13093

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.795 0.005 1.000 0.000 0.898 0.004 0.885 0.005 0.990 0.000 0.808 0.004 Download
Estate fingerprints 0.876 0.005 0.940 0.000 0.908 0.004 0.900 0.000 0.960 0.000 0.813 0.005 Download
MACCS fingerprints 0.854 0.007 0.970 0.004 0.912 0.006 0.906 0.005 0.960 0.000 0.828 0.010 Download
Daylight fingerprints 0.680 0.000 1.000 0.000 0.840 0.000 0.810 0.000 0.999 0.003 0.720 0.000 Download
ECFP2 fingerprints 0.908 0.004 0.988 0.004 0.948 0.004 0.944 0.005 0.990 0.000 0.898 0.004 Download
ECFP4 fingerprints 0.968 0.004 0.998 0.000 0.983 0.005 0.983 0.005 1.000 0.000 0.968 0.004 Download
ECFP6 fingerprints 0.975 0.007 1.000 0.000 0.989 0.003 0.989 0.003 1.000 0.000 0.975 0.007 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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