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E-mail: biomed@csu.edu.cn
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Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
| Uniprot primary ID | Q13133 |
| PDB ID | 1UHL 5AVI 5AVL 3IPU 3IPQ 3IPS |
| DrugBank ID | |
| BioGrid ID | 115373 |
| GuidetoPHARMACOLOGY ID | 602 |
| PharmGKB ID | PA31751 |
| KEGG ID | hsa:10062 |
| DIP ID | |
| STRING ID | 9606.ENSP00000387946 |
| IntAct ID | Q13133 |
| DMDM | 23503089 |
| BRENDA | |
| Reactome | R-HSA-383280 |
| SignaLink | Q13133 |
| BioCyc | |
| Entrez Gene (Gene ID) | 10062 |
| BindingDB | Q13133 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.863 | 0.005 | 0.917 | 0.000 | 0.890 | 0.000 | 0.882 | 0.004 | 0.950 | 0.000 | 0.774 | 0.005 | Download |
| Estate fingerprints | 0.774 | 0.005 | 0.866 | 0.005 | 0.820 | 0.000 | 0.810 | 0.000 | 0.910 | 0.000 | 0.639 | 0.006 | Download |
| MACCS fingerprints | 0.789 | 0.003 | 0.849 | 0.000 | 0.819 | 0.003 | 0.810 | 0.000 | 0.910 | 0.000 | 0.637 | 0.005 | Download |
| Daylight fingerprints | 0.784 | 0.007 | 0.958 | 0.005 | 0.871 | 0.006 | 0.859 | 0.003 | 0.920 | 0.000 | 0.754 | 0.007 | Download |
| ECFP2 fingerprints | 0.929 | 0.007 | 0.949 | 0.005 | 0.939 | 0.006 | 0.939 | 0.006 | 0.990 | 0.000 | 0.878 | 0.009 | Download |
| ECFP4 fingerprints | 0.952 | 0.004 | 0.974 | 0.000 | 0.963 | 0.005 | 0.962 | 0.004 | 0.990 | 0.000 | 0.928 | 0.006 | Download |
| ECFP6 fingerprints | 0.936 | 0.005 | 0.984 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.924 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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