Target name

Q13133: Oxysterols receptor LXR-alpha


  Protein function

Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).

  Database links

Uniprot primary ID Q13133
PDB ID 1UHL 5AVI 5AVL 3IPU 3IPQ 3IPS
DrugBank ID
BioGrid ID 115373
GuidetoPHARMACOLOGY ID 602
PharmGKB ID PA31751
KEGG ID hsa:10062
DIP ID
STRING ID 9606.ENSP00000387946
IntAct ID Q13133
DMDM 23503089
BRENDA
Reactome R-HSA-383280
SignaLink Q13133
BioCyc
Entrez Gene (Gene ID) 10062
BindingDB Q13133

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.863 0.005 0.917 0.000 0.890 0.000 0.882 0.004 0.950 0.000 0.774 0.005 Download
Estate fingerprints 0.774 0.005 0.866 0.005 0.820 0.000 0.810 0.000 0.910 0.000 0.639 0.006 Download
MACCS fingerprints 0.789 0.003 0.849 0.000 0.819 0.003 0.810 0.000 0.910 0.000 0.637 0.005 Download
Daylight fingerprints 0.784 0.007 0.958 0.005 0.871 0.006 0.859 0.003 0.920 0.000 0.754 0.007 Download
ECFP2 fingerprints 0.929 0.007 0.949 0.005 0.939 0.006 0.939 0.006 0.990 0.000 0.878 0.009 Download
ECFP4 fingerprints 0.952 0.004 0.974 0.000 0.963 0.005 0.962 0.004 0.990 0.000 0.928 0.006 Download
ECFP6 fingerprints 0.936 0.005 0.984 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.924 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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