TargetNet
  Target name

Q13224: Glutamate receptor ionotropic, NMDA 2B

  Protein function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

  Database links
Uniprot primary ID Q13224
PDB ID 1S2S 2IPV 1S11
DrugBank ID DB04896 DB00996 DB00502 DB00949 DB01174 DB00312 DB00418
BioGrid ID 109161
GuidetoPHARMACOLOGY ID 457
PharmGKB ID PA28980
KEGG ID hsa:2904
DIP ID DIP-41002N
STRING ID 9606.ENSP00000279593
IntAct ID Q13224
DMDM 14548162
BRENDA
Reactome R-HSA-442729 R-HSA-5673001 R-HSA-3928662 R-HSA-438066 R-HSA-442982
SignaLink Q13224
BioCyc
Entrez Gene (Gene ID) 2904
BindingDB Q13224
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.914 0.007 0.836 0.004 0.875 0.005 0.880 0.005 0.957 0.005 0.753 0.011 Download
Estate fingerprints 0.813 0.008 0.803 0.007 0.808 0.006 0.807 0.005 0.899 0.003 0.614 0.015 Download
MACCS fingerprints 0.887 0.007 0.823 0.006 0.855 0.005 0.860 0.007 0.925 0.005 0.711 0.007 Download
Daylight fingerprints 0.724 0.007 0.814 0.004 0.769 0.003 0.758 0.004 0.860 0.000 0.540 0.007 Download
ECFP2 fingerprints 0.949 0.003 0.891 0.007 0.920 0.005 0.924 0.005 0.981 0.003 0.843 0.008 Download
ECFP4 fingerprints 0.964 0.007 0.928 0.004 0.946 0.005 0.946 0.005 0.990 0.000 0.891 0.006 Download
ECFP6 fingerprints 0.949 0.006 0.969 0.007 0.959 0.003 0.959 0.003 0.990 0.000 0.920 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn