Details-Calcnet-TargetNet

Target name

Q13224: Glutamate receptor ionotropic, NMDA 2B

Protein function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

Database links

Uniprot primary ID	Q13224
PDB ID	1S2S 2IPV 1S11
DrugBank ID	DB04896 DB00996 DB00502 DB00949 DB01174 DB00312 DB00418
BioGrid ID	109161
GuidetoPHARMACOLOGY ID	457
PharmGKB ID	PA28980
KEGG ID	hsa:2904
DIP ID	DIP-41002N
STRING ID	9606.ENSP00000279593
IntAct ID	Q13224
DMDM	14548162
BRENDA
Reactome	R-HSA-442729 R-HSA-5673001 R-HSA-3928662 R-HSA-438066 R-HSA-442982
SignaLink	Q13224
BioCyc
Entrez Gene (Gene ID)	2904
BindingDB	Q13224

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.914	0.007	0.836	0.004	0.875	0.005	0.880	0.005	0.957	0.005	0.753	0.011	Download
Estate fingerprints	0.813	0.008	0.803	0.007	0.808	0.006	0.807	0.005	0.899	0.003	0.614	0.015	Download
MACCS fingerprints	0.887	0.007	0.823	0.006	0.855	0.005	0.860	0.007	0.925	0.005	0.711	0.007	Download
Daylight fingerprints	0.724	0.007	0.814	0.004	0.769	0.003	0.758	0.004	0.860	0.000	0.540	0.007	Download
ECFP2 fingerprints	0.949	0.003	0.891	0.007	0.920	0.005	0.924	0.005	0.981	0.003	0.843	0.008	Download
ECFP4 fingerprints	0.964	0.007	0.928	0.004	0.946	0.005	0.946	0.005	0.990	0.000	0.891	0.006	Download
ECFP6 fingerprints	0.949	0.006	0.969	0.007	0.959	0.003	0.959	0.003	0.990	0.000	0.920	0.005	Download

Download datasets

Positive dataset

Negative dataset