Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
| Uniprot primary ID | Q13258 |
| PDB ID | |
| DrugBank ID | DB00716 |
| BioGrid ID | 111701 |
| GuidetoPHARMACOLOGY ID | 338 |
| PharmGKB ID | PA285 |
| KEGG ID | hsa:5729 |
| DIP ID | |
| STRING ID | 9606.ENSP00000303424 |
| IntAct ID | |
| DMDM | 2495009 |
| BRENDA | |
| Reactome | R-HSA-391908 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5729 |
| BindingDB | Q13258 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.817 | 0.008 | 0.963 | 0.003 | 0.890 | 0.005 | 0.881 | 0.006 | 0.970 | 0.000 | 0.789 | 0.006 | Download |
| Estate fingerprints | 0.840 | 0.000 | 0.820 | 0.003 | 0.830 | 0.000 | 0.831 | 0.003 | 0.890 | 0.000 | 0.662 | 0.004 | Download |
| MACCS fingerprints | 0.712 | 0.004 | 0.886 | 0.005 | 0.799 | 0.003 | 0.779 | 0.003 | 0.910 | 0.000 | 0.606 | 0.007 | Download |
| Daylight fingerprints | 0.751 | 0.006 | 0.787 | 0.005 | 0.769 | 0.003 | 0.764 | 0.005 | 0.806 | 0.005 | 0.535 | 0.005 | Download |
| ECFP2 fingerprints | 0.901 | 0.006 | 0.975 | 0.005 | 0.938 | 0.004 | 0.933 | 0.005 | 0.990 | 0.000 | 0.878 | 0.006 | Download |
| ECFP4 fingerprints | 0.941 | 0.003 | 0.999 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.941 | 0.003 | Download |
| ECFP6 fingerprints | 0.912 | 0.004 | 1.000 | 0.000 | 0.956 | 0.005 | 0.952 | 0.004 | 0.990 | 0.000 | 0.912 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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