Target name

Q13258: Prostaglandin D2 receptor


  Protein function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).

  Database links

Uniprot primary ID Q13258
PDB ID
DrugBank ID DB00716
BioGrid ID 111701
GuidetoPHARMACOLOGY ID 338
PharmGKB ID PA285
KEGG ID hsa:5729
DIP ID
STRING ID 9606.ENSP00000303424
IntAct ID
DMDM 2495009
BRENDA
Reactome R-HSA-391908 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5729
BindingDB Q13258

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.817 0.008 0.963 0.003 0.890 0.005 0.881 0.006 0.970 0.000 0.789 0.006 Download
Estate fingerprints 0.840 0.000 0.820 0.003 0.830 0.000 0.831 0.003 0.890 0.000 0.662 0.004 Download
MACCS fingerprints 0.712 0.004 0.886 0.005 0.799 0.003 0.779 0.003 0.910 0.000 0.606 0.007 Download
Daylight fingerprints 0.751 0.006 0.787 0.005 0.769 0.003 0.764 0.005 0.806 0.005 0.535 0.005 Download
ECFP2 fingerprints 0.901 0.006 0.975 0.005 0.938 0.004 0.933 0.005 0.990 0.000 0.878 0.006 Download
ECFP4 fingerprints 0.941 0.003 0.999 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.941 0.003 Download
ECFP6 fingerprints 0.912 0.004 1.000 0.000 0.956 0.005 0.952 0.004 0.990 0.000 0.912 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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