Target name

Q13547: Histone deacetylase 1


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

  Database links

Uniprot primary ID Q13547
PDB ID 1TYI 4BKX
DrugBank ID DB02546
BioGrid ID 109315
GuidetoPHARMACOLOGY ID 2658
PharmGKB ID PA29226
KEGG ID hsa:3065
DIP ID DIP-24184N
STRING ID 9606.ENSP00000362649
IntAct ID Q13547
DMDM 2498443
BRENDA 3.5.1.98
Reactome R-HSA-201722 R-HSA-1538133 R-HSA-427413 R-HSA-2644606 R-HSA-193670 R-HSA-2122947 R-HSA-3769402 R-HSA-3214815 R-HSA-73762 R-HSA-983231 R-HSA-2894862 R-HSA-2173795 R-HSA-2173796 R-HSA-4641265
SignaLink
BioCyc
Entrez Gene (Gene ID) 3065
BindingDB Q13547

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.853 0.005 0.925 0.000 0.889 0.003 0.880 0.000 0.950 0.000 0.771 0.003 Download
Estate fingerprints 0.880 0.000 0.760 0.005 0.820 0.000 0.830 0.000 0.910 0.000 0.647 0.005 Download
MACCS fingerprints 0.830 0.000 0.890 0.004 0.860 0.000 0.859 0.003 0.940 0.000 0.727 0.005 Download
Daylight fingerprints 0.711 0.003 0.775 0.005 0.743 0.005 0.739 0.003 0.810 0.000 0.490 0.000 Download
ECFP2 fingerprints 0.970 0.000 0.930 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.902 0.004 Download
ECFP4 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.942 0.004 Download
ECFP6 fingerprints 0.940 0.000 0.980 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.929 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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