Target name

Q13627: Dual specificity tyrosine-phosphorylation-regulated kinase 1A


  Protein function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

  Database links

Uniprot primary ID Q13627
PDB ID 4YLL 2WO6 3ANR 4YLK 4AZE 3ANQ 4YLJ 4NCT 4MQ2 4MQ1 5AIK 4YU2 2VX3
DrugBank ID
BioGrid ID 108192
GuidetoPHARMACOLOGY ID 2009
PharmGKB ID PA27545
KEGG ID hsa:1859
DIP ID DIP-39750N
STRING ID 9606.ENSP00000381932
IntAct ID Q13627
DMDM 3219996
BRENDA 2.7.12.1
Reactome R-HSA-1538133
SignaLink Q13627
BioCyc
Entrez Gene (Gene ID) 1859
BindingDB Q13627

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.759 0.013 0.907 0.005 0.833 0.005 0.819 0.009 0.920 0.000 0.674 0.013 Download
Estate fingerprints 0.700 0.000 0.732 0.007 0.716 0.007 0.711 0.006 0.800 0.005 0.434 0.008 Download
MACCS fingerprints 0.746 0.013 0.820 0.008 0.783 0.008 0.772 0.010 0.885 0.005 0.567 0.013 Download
Daylight fingerprints 0.619 0.003 0.957 0.004 0.788 0.004 0.741 0.003 0.897 0.005 0.610 0.005 Download
ECFP2 fingerprints 0.853 0.009 0.841 0.011 0.847 0.011 0.847 0.011 0.924 0.005 0.698 0.023 Download
ECFP4 fingerprints 0.808 0.014 0.928 0.010 0.868 0.006 0.858 0.006 0.930 0.000 0.741 0.014 Download
ECFP6 fingerprints 0.738 0.010 0.962 0.007 0.850 0.007 0.830 0.009 0.918 0.004 0.715 0.013 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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