Target name

Q13639: 5-hydroxytryptamine receptor 4


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID Q13639
PDB ID
DrugBank ID DB00904 DB08810 DB00604 DB01233 DB01049
BioGrid ID
GuidetoPHARMACOLOGY ID 9
PharmGKB ID PA29557
KEGG ID hsa:3360
DIP ID
STRING ID
IntAct ID
DMDM 12644029
BRENDA
Reactome R-HSA-390666 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 3360
BindingDB Q13639

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.920 0.005 0.946 0.008 0.933 0.005 0.933 0.005 0.970 0.000 0.865 0.005 Download
Estate fingerprints 0.869 0.007 0.839 0.003 0.854 0.005 0.856 0.005 0.930 0.000 0.709 0.007 Download
MACCS fingerprints 0.915 0.005 0.857 0.004 0.886 0.005 0.889 0.003 0.957 0.005 0.772 0.006 Download
Daylight fingerprints 0.810 0.005 1.000 0.000 0.907 0.005 0.897 0.005 0.970 0.000 0.820 0.005 Download
ECFP2 fingerprints 0.940 0.000 0.980 0.000 0.960 0.000 0.960 0.000 0.980 0.000 0.920 0.000 Download
ECFP4 fingerprints 0.930 0.000 1.000 0.000 0.969 0.003 0.966 0.005 0.990 0.000 0.936 0.005 Download
ECFP6 fingerprints 0.922 0.004 0.998 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.929 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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