G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
| Uniprot primary ID | Q14416 |
| PDB ID | 4XAS 5CNJ 4XAQ 5CNI |
| DrugBank ID | |
| BioGrid ID | 109169 |
| GuidetoPHARMACOLOGY ID | 290 |
| PharmGKB ID | PA28991 |
| KEGG ID | hsa:2912 |
| DIP ID | DIP-59826N |
| STRING ID | 9606.ENSP00000378492 |
| IntAct ID | Q14416 |
| DMDM | 76803802 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-420499 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2912 |
| BindingDB | Q14416 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.930 | 0.005 | 0.872 | 0.005 | 0.901 | 0.003 | 0.906 | 0.005 | 0.960 | 0.000 | 0.807 | 0.007 | Download |
| Estate fingerprints | 0.809 | 0.009 | 0.757 | 0.005 | 0.783 | 0.005 | 0.790 | 0.008 | 0.860 | 0.000 | 0.570 | 0.013 | Download |
| MACCS fingerprints | 0.776 | 0.005 | 0.764 | 0.004 | 0.770 | 0.005 | 0.772 | 0.004 | 0.869 | 0.003 | 0.540 | 0.007 | Download |
| Daylight fingerprints | 0.875 | 0.007 | 0.801 | 0.000 | 0.838 | 0.004 | 0.846 | 0.005 | 0.875 | 0.005 | 0.677 | 0.005 | Download |
| ECFP2 fingerprints | 0.934 | 0.007 | 0.898 | 0.005 | 0.916 | 0.005 | 0.919 | 0.003 | 0.980 | 0.000 | 0.832 | 0.006 | Download |
| ECFP4 fingerprints | 0.939 | 0.003 | 0.957 | 0.005 | 0.948 | 0.004 | 0.948 | 0.004 | 0.990 | 0.000 | 0.897 | 0.005 | Download |
| ECFP6 fingerprints | 0.929 | 0.003 | 0.977 | 0.005 | 0.953 | 0.005 | 0.952 | 0.004 | 0.990 | 0.000 | 0.910 | 0.008 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |