Target name

Q14416: Metabotropic glutamate receptor 2


  Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

  Database links

Uniprot primary ID Q14416
PDB ID 4XAS 5CNJ 4XAQ 5CNI
DrugBank ID
BioGrid ID 109169
GuidetoPHARMACOLOGY ID 290
PharmGKB ID PA28991
KEGG ID hsa:2912
DIP ID DIP-59826N
STRING ID 9606.ENSP00000378492
IntAct ID Q14416
DMDM 76803802
BRENDA
Reactome R-HSA-418594 R-HSA-420499
SignaLink
BioCyc
Entrez Gene (Gene ID) 2912
BindingDB Q14416

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.930 0.005 0.872 0.005 0.901 0.003 0.906 0.005 0.960 0.000 0.807 0.007 Download
Estate fingerprints 0.809 0.009 0.757 0.005 0.783 0.005 0.790 0.008 0.860 0.000 0.570 0.013 Download
MACCS fingerprints 0.776 0.005 0.764 0.004 0.770 0.005 0.772 0.004 0.869 0.003 0.540 0.007 Download
Daylight fingerprints 0.875 0.007 0.801 0.000 0.838 0.004 0.846 0.005 0.875 0.005 0.677 0.005 Download
ECFP2 fingerprints 0.934 0.007 0.898 0.005 0.916 0.005 0.919 0.003 0.980 0.000 0.832 0.006 Download
ECFP4 fingerprints 0.939 0.003 0.957 0.005 0.948 0.004 0.948 0.004 0.990 0.000 0.897 0.005 Download
ECFP6 fingerprints 0.929 0.003 0.977 0.005 0.953 0.005 0.952 0.004 0.990 0.000 0.910 0.008 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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