Details-Calcnet-TargetNet

Target name

Q14432: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Protein function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Database links

Uniprot primary ID	Q14432
PDB ID	1LRC
DrugBank ID	DB01427 DB00922 DB01166 DB01223 DB08811 DB05266 DB00201
BioGrid ID	111165
GuidetoPHARMACOLOGY ID	1298
PharmGKB ID	PA33126
KEGG ID	hsa:5139
DIP ID	DIP-42197N
STRING ID	9606.ENSP00000351957
IntAct ID	Q14432
DMDM	47117888
BRENDA	3.1.4.17
Reactome	R-HSA-418457 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID)	5139
BindingDB	Q14432

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.828	0.011	0.952	0.006	0.890	0.009	0.883	0.009	0.952	0.004	0.786	0.016	Download
Estate fingerprints	0.876	0.012	0.824	0.005	0.850	0.005	0.854	0.007	0.920	0.000	0.700	0.013	Download
MACCS fingerprints	0.854	0.013	0.878	0.005	0.866	0.007	0.862	0.009	0.940	0.000	0.728	0.013	Download
Daylight fingerprints	0.766	0.005	0.902	0.008	0.834	0.005	0.821	0.003	0.858	0.004	0.670	0.012	Download
ECFP2 fingerprints	0.906	0.008	0.888	0.013	0.897	0.009	0.897	0.009	0.960	0.000	0.792	0.018	Download
ECFP4 fingerprints	0.911	0.003	0.959	0.008	0.935	0.005	0.931	0.006	0.974	0.005	0.865	0.010	Download
ECFP6 fingerprints	0.907	0.005	0.985	0.003	0.946	0.005	0.943	0.005	0.980	0.000	0.896	0.005	Download

Download datasets

Positive dataset

Negative dataset