Target name

Q14432: cGMP-inhibited 3',5'-cyclic phosphodiesterase A


  Protein function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

  Database links

Uniprot primary ID Q14432
PDB ID 1LRC
DrugBank ID DB01427 DB00922 DB01166 DB01223 DB08811 DB05266 DB00201
BioGrid ID 111165
GuidetoPHARMACOLOGY ID 1298
PharmGKB ID PA33126
KEGG ID hsa:5139
DIP ID DIP-42197N
STRING ID 9606.ENSP00000351957
IntAct ID Q14432
DMDM 47117888
BRENDA 3.1.4.17
Reactome R-HSA-418457 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5139
BindingDB Q14432

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.828 0.011 0.952 0.006 0.890 0.009 0.883 0.009 0.952 0.004 0.786 0.016 Download
Estate fingerprints 0.876 0.012 0.824 0.005 0.850 0.005 0.854 0.007 0.920 0.000 0.700 0.013 Download
MACCS fingerprints 0.854 0.013 0.878 0.005 0.866 0.007 0.862 0.009 0.940 0.000 0.728 0.013 Download
Daylight fingerprints 0.766 0.005 0.902 0.008 0.834 0.005 0.821 0.003 0.858 0.004 0.670 0.012 Download
ECFP2 fingerprints 0.906 0.008 0.888 0.013 0.897 0.009 0.897 0.009 0.960 0.000 0.792 0.018 Download
ECFP4 fingerprints 0.911 0.003 0.959 0.008 0.935 0.005 0.931 0.006 0.974 0.005 0.865 0.010 Download
ECFP6 fingerprints 0.907 0.005 0.985 0.003 0.946 0.005 0.943 0.005 0.980 0.000 0.896 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn